Skip to content
JuicerAdvicesDrink safety, answered

Five Hour Energy Drink Side Effects: What You Should Know

The verdict
Five Hour Energy drinks can cause side effects and are safe only with limits. Stick to about one 2 oz shot daily. Their 230 mg caffeine and B-vitamin content can cause jitteriness and raise heart rate if overused.

Say you start your day with one 2 oz Five Hour Energy shot, delivering 230 mg of caffeine and B-vitamins to boost alertness. This amount is roughly equal to a strong 12 oz coffee but in a concentrated form.

Understanding the side effects and who should avoid these energy shots helps you decide if they fit your health needs and lifestyle.

Side Effects of Five Hour Energy Drinks

Five Hour Energy drink side effects come mainly from its high caffeine content and B-vitamin blend. Each 2 oz shot delivers about 230 mg of caffeine, which is enough to cause jitteriness, rapid heartbeat, insomnia, and headaches in sensitive people or when consumed in excess.

a small clear glass filled with amber colored energy drink on wooden table
A typical serving size of Five Hour Energy drink contains high caffeine levels.

This caffeine level is comparable to about two strong cups of coffee and can trigger these side effects within an hour of drinking. The zero sugar and calorie content means these symptoms aren’t driven by sugar spikes but by caffeine and other ingredients like amino acids and B-vitamins, which may also contribute to an energized feeling or, rarely, discomfort.

Common side effects include feeling restless or anxious, a racing heart, difficulty falling asleep, and headaches. These often appear if you drink more than one shot per day or combine it with other caffeine sources. The acidity and sodium in the formula are low and usually not a concern but might irritate sensitive stomachs or worsen reflux.

Side EffectCauseWhen It Happens
JitterinessHigh caffeineMore than 230 mg caffeine in short time
Rapid heartbeatCaffeine stimulant effectShortly after drinking
InsomniaCaffeine blocks sleep signalsLater in the day or evening
HeadachesCaffeine withdrawal or excessWith overuse or sudden stop
Common Five Hour Energy side effects and their causes.
Worked example
Say you drink a 2 oz shot of Five Hour Energy in the morning and then have a 12 oz coffee later that day. That totals about 325 mg of caffeine, which may cause nervousness and trouble sleeping by evening in people sensitive to caffeine.
Drinks2 oz Five Hour Energy + 12 oz coffee
Caffeine230 mg + 95 mg = 325 mg
Good for quick caffeine boost
5-hour ENERGY GRAPE Flavor
The 5-hour ENERGY GRAPE Flavor offers a fast, no-sugar caffeine lift packed in a small, convenient bottle.
See it on Amazon

People Who Should Avoid or Limit Five Hour Energy Drinks

5 hour energy side effects in adults are more likely and more severe in people with heart conditions, high blood pressure, or anxiety disorders. The stimulant effect of 230 mg caffeine per shot can worsen these problems, raising heart rate and blood pressure.

Daily use or excessive intake increases the risk of dependence, making it harder to feel alert without the drink and causing withdrawal symptoms like headaches or fatigue when stopping. People sensitive to caffeine should limit intake or avoid it altogether.

Consider avoiding Five Hour Energy if you have:
Heart disease or arrhythmias
High blood pressure not well controlled
Anxiety or panic disorder
Sensitivity to caffeine
Pregnancy or breastfeeding
Medications affected by caffeine or B-vitamins

Pregnant or breastfeeding women are advised to limit caffeine intake to about 200 mg daily. One Five Hour Energy shot exceeds this and should be avoided or replaced with lower-caffeine options. Some medications, including certain antibiotics, antidepressants, and blood thinners, interact with caffeine or B-vitamin levels, making use risky without medical advice.

5 hour energy side effects of daily use can include liver strain in rare cases, though this is not common at recommended doses. Still, those with liver disease should consult their healthcare provider before use. Individual tolerance varies widely, so following your care team’s advice is crucial.

Personalized advice matters
Your health history, medications, and conditions affect how your body handles caffeine and B-vitamins. Don’t rely on general rules alone; ask your doctor or pharmacist what’s safe for you.
When to call your doctor
Seek help if you experience chest pain, severe palpitations, fainting, or swelling after drinking Five Hour Energy.
Chest pain or tightness
Rapid or irregular heartbeat
Dizziness or fainting
Swelling of face, lips, tongue, or throat
Energy Shots to Consider
Choose based on caffeine content, flavor, and sugar-free formula
Sugar-free boost
5-hour ENERGY Extra Strength Grape Flavor
This grape-flavored shot delivers 230 mg of caffeine with zero sugar, providing a strong, fast energy lift without added calories. Its B-vitamin and amino acid blend supports alertness but can cause jitteriness if you exceed one shot per day.
See it on Amazon
zero sugar boost
5-hour ENERGY Extra Strength Berry Flavor
This berry-flavored energy shot offers the same 230 mg caffeine and zero sugar formula as the grape variant, combining strong caffeine with B-vitamins and amino acids for alertness. It’s ideal if you want a flavorful, portable energy boost but should be limited to one shot daily to avoid side effects.
See it on Amazon

Safe Amounts of Five Hour Energy to Drink

Stick to one 2 oz shot of Five Hour Energy per day, which contains about 230 mg of caffeine. This amount generally stays within safe caffeine limits for most adults, but going beyond this can increase side effects.

Most healthy adults can safely consume up to 400 mg of caffeine daily from all sources combined. For comparison, an 8 oz cup of brewed coffee has about 95 mg. Drinking more than one shot of Five Hour Energy quickly pushes you close to or over that limit.

Avoid taking multiple shots in a short period. Caffeine accumulates in your system, and consuming too much too fast can cause jitteriness, rapid heartbeat, and anxiety. Your body also develops tolerance over time, but acute overdose effects remain a risk.

Caffeine stimulates your central nervous system. High doses overload this system, causing those side effects and, in extreme cases, heart rhythm disturbances. B-vitamins in the energy shot add no immediate risk at these doses but may cause a harmless bright urine color.

1
Check your total caffeine intake
Add caffeine from all sources before drinking an energy shot.
2
Limit to one 2 oz shot daily
Stick to this to avoid side effects like jitteriness and rapid heart rate.
3
Space consumption
Avoid multiple shots within a few hours to prevent caffeine overload.

Safer Alternatives to Five Hour Energy Drinks

Consider energy drinks with less caffeine or sugar to reduce side effects like those seen with Five Hour Energy or Monster Energy drinks. Options with around 80 to 150 mg caffeine per serving are common and often gentler.

two clear bottles with different colored energy drinks on white countertop
Lower caffeine energy drinks can be gentler alternatives to Five Hour Energy.

Non-caffeinated alternatives include drinking enough water, eating balanced meals with protein and complex carbs, and taking short breaks for physical activity. These support steady energy without the crash or jitters.

Some natural sources like green tea provide a lower caffeine dose plus antioxidants. Herbal teas and electrolyte drinks hydrate and refresh without overstimulation.

Good for Lower Side Effects
Lower caffeine content reduces risk of jitteriness and heart rate spikes
Often contains less sugar, helping maintain stable blood sugar
Hydrating options support overall well-being
Not for Quick High Caffeine
May not provide as fast or strong an energy boost
Some alternatives require more time or effort to prepare
Useful here
5-hour ENERGY GRAPE Flavor
This 5-hour ENERGY shot has a known caffeine content and a formula that some users find tolerable for occasional use.
See it on Amazon

For more on how to choose safer energy drinks or boost your energy naturally, see our guides on 5 Hour Energy Dangers and Smoothie Side Effects.

When to Contact Your Doctor About Energy Drink Side Effects

Severe side effects from Five Hour Energy or other caffeine drinks can require immediate medical attention. The FDA has received adverse event reports linking high caffeine intake to symptoms like chest pain, irregular or fast heartbeats, fainting, and severe headaches.

Call your doctor or emergency services right away if you experience chest pain, palpitations that don’t stop, fainting, confusion, seizures, or a severe headache. Allergic reactions such as swelling of the face or throat, difficulty breathing, or rash also need urgent care.

Feelings of extreme anxiety, agitation, or confusion after drinking an energy shot are warning signs to seek help quickly. These symptoms can indicate a serious reaction to caffeine or other ingredients.

Everyone reacts differently to caffeine and B vitamins in these drinks. Even if you usually tolerate caffeine well, factors like other medications, heart conditions, or anxiety disorders can increase your risk of severe side effects.

If you’re unsure whether your symptoms are serious, it’s better to be cautious and contact a healthcare professional. They can evaluate your condition and guide the safest next steps.

When to call your doctor
Seek immediate medical help if you have any of these after drinking Five Hour Energy or a similar product.
Chest pain or pressure
Severe or irregular heartbeats
Fainting or loss of consciousness
Confusion or seizures
Severe headache
Difficulty breathing or swelling of face/throat
Severe anxiety or agitation

Frequently Asked Questions

What are the most common side effects of Five Hour Energy drinks?
The most common side effects include jitteriness, increased heart rate, and restlessness due to the high caffeine content. Some people may also experience headaches or digestive upset from the B-vitamin blend. These effects usually appear within an hour of consumption.
Can drinking Five Hour Energy daily harm my liver or heart?
Drinking one shot daily is unlikely to harm your liver or heart if you are healthy. However, the high caffeine dose can strain the heart and raise blood pressure, especially if you have preexisting conditions. The B vitamins in Five Hour Energy are generally safe but excessive intake over time might cause side effects.
Is it safe to take more than one Five Hour Energy shot in a day?
Taking more than one 2 oz shot a day is not recommended because you can quickly exceed safe caffeine limits. More than 230 mg of caffeine from these shots may increase side effects like rapid heartbeat, anxiety, and insomnia. If you already consumed one, wait several hours before considering another and monitor how you feel.
Are there natural alternatives to Five Hour Energy for boosting energy?
Yes, natural alternatives include green tea, which has less caffeine and antioxidants, or small amounts of black coffee. Staying hydrated and eating balanced meals with protein and complex carbs also supports natural energy. These options tend to cause fewer side effects than concentrated energy shots.
When should I seek medical help after drinking an energy shot?
Seek medical help if you experience chest pain, severe palpitations, fainting, difficulty breathing, or confusion after drinking an energy shot. These symptoms could signal a serious reaction to caffeine. For milder symptoms like headache or jitteriness, rest and hydration usually help, but persistent or worsening signs need evaluation.
Keep reading
muscle milk side effectsSide effects of protein shakes and energy supplements
Is Lemon Water Healthy? Benefits and Side EffectsEffects of lemon water on digestion and energy
Do Energy Drinks Raise Blood Pressure? The Shocking TruthHow energy drinks affect blood pressure and heart health