Paxlovid and Alcohol: How Long Should You Wait?

Paxlovid (nirmatrelvir and ritonavir) is a new antiviral drug developed by Pfizer that has been authorized for emergency use by the FDA to treat COVID-19. Many people wonder if it’s safe to drink alcohol while taking Paxlovid or how long they should wait after taking the drug to consume alcohol.

In this article, we’ll examine the available research and provide guidance on alcohol consumption while taking Paxlovid.

Paxlovid and Alcohol: How Long Should You Wait?

How does Paxlovid work?

Paxlovid is a combination of two antiviral drugs, nirmatrelvir and ritonavir, that work together to block the activity of the main protease enzyme in SARS-CoV-2, the virus that causes COVID-19. This enzyme is essential for the virus to replicate and spread throughout the body. By inhibiting its activity, Paxlovid can reduce the severity and duration of COVID-19 symptoms.

Can alcohol interfere with Paxlovid’s effectiveness?

There is currently no evidence to suggest that alcohol consumption interferes with the effectiveness of Paxlovid. However, alcohol can weaken the immune system and make it harder for the body to fight off infections, including COVID-19. Additionally, excessive alcohol consumption can lead to liver damage, which could potentially affect the body’s ability to metabolize Paxlovid.

How long should you wait to drink alcohol after taking Paxlovid?

There is no specific guidance on how long you should wait to drink alcohol after taking Paxlovid. However, it’s generally recommended that you avoid alcohol while you’re taking any medication, especially if it has the potential to interact with alcohol. As a precaution, it’s best to wait until you have finished your course of Paxlovid before drinking alcohol.

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What are the potential side effects of Paxlovid?

Like all medications, Paxlovid can cause side effects. The most common side effects reported in clinical trials include diarrhea, nausea, and vomiting. These side effects are generally mild and go away on their own within a few days. However, if you experience severe or persistent side effects, you should contact your healthcare provider.

What are the risks of drinking alcohol while taking Paxlovid?

Although there is no proof that alcohol will impede the efficacy of Paxlovid, it is crucial to consider the potential hazards. Alcohol can cause dehydration, which can worsen some of the side effects of Paxlovid, such as diarrhea and nausea. Additionally, alcohol can impair judgment and motor function, which could be dangerous if you’re experiencing any of the cognitive or physical side effects of Paxlovid.

How can you reduce the risks of drinking alcohol while taking Paxlovid?

If you do choose to drink alcohol while taking Paxlovid, it’s important to do so in moderation. This means limiting your intake to one drink per day for women and two drinks per day for men. It’s also important to drink plenty of water to stay hydrated and avoid mixing alcohol with other medications or drugs.

What other precautions should you take while taking Paxlovid?

In addition to avoiding alcohol, there are several other precautions you should take while taking Paxlovid. These include:

  • Taking the medication exactly as prescribed by your healthcare provider
  • Letting your healthcare provider know if you experience any side effects or if your symptoms worsen
  • Avoiding close contact with others, especially if you’re still contagious
  • Wearing a mask and practicing good hand hygiene to prevent the spread of COVID-19
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While there is no specific guidance on how long you should wait to drink alcohol after taking Paxlovid, it’s generally recommended to avoid alcohol while taking any medication.

Although there is no evidence of alcohol affecting the effectiveness of Paxlovid, it is important to be aware of potential risks and take precautions to minimize them. If you have any concerns about drinking alcohol while taking Paxlovid, talk to your healthcare provider.


  1. Pfizer. (2021). Paxlovid: Highlights of Prescribing Information. Retrieved from
  2. Centers for Disease Control and Prevention. (2022). Alcohol Use and Your Health. Retrieved from
  3. National Institute on Alcohol Abuse and Alcoholism. (2022). Alcohol Facts and Statistics. Retrieved from
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Hi, I'm Emily Jones! I'm a health enthusiast and foodie, and I'm passionate about juicing, smoothies, and all kinds of nutritious beverages. Through my popular blog, I share my knowledge and love for healthy drinks with others.